Analog Genetic Circuits (Microbes as Machines)

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Repressilator [1]. Image from Wikipedia article.


Download Pre-Discussion Questions (PDF)

Such 'rational network design' may lead both to the engineering of new cellular behaviours and to an improved understanding of naturally occurring networks [2].

Required Reading/Viewing

Error fetching PMID 10659856:
Error fetching PMID 10659857:
  1. Error fetching PMID 10659856: [Elowitz2000]
    Describes the artificial "repressilator" circuit. Also, view the movie of it in action.
  2. Error fetching PMID 10659857: [Gardner2000]
    Describes an artificial "toggle switch" circuit.
  3. Explanation of the toggle switch and repressilator by J. Chris Anderson (YouTube) [Anderson2014]
All Medline abstracts: PubMed | HubMed

Assigned Papers

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  1. Error fetching PMID 19478183: [Friedland2009]
    Bacteria that can count to three.
  2. Error fetching PMID 22178928: [Prindle2012]
    Synchronization and modulation of oscillations across multiple cell populations.
All Medline abstracts: PubMed | HubMed

Additional Resources

  1. Repressilator in TinkerCell (YouTube) [Chandran2011]
    Movie shows how to create and model the repressilator in TinkerCell