BioBricks and Standardized Genetic Parts (Microbes as Machines)

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Standard BioBrick Assembly (image from


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[T]he engineering of biology remains complex because we have never made it simple.
--attributed to Tom Knight

Required Reading

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  1. Knight T Idempotent Vector Design for Standard Assembly of Biobricks 2005 [Knight2003]
    Classic paper first describing BioBricks.
  2. Error fetching PMID 16306983: [Endy2005]
    Describes how synthetic biology perspective differs from "mere" recombinant DNA technology and metabolic engineering. Introduces key concepts such as standardization, decoupling, abstraction,
  3. Error fetching PMID 24811510: [Vilanova2014]
    Overview of the iGEM competition.
All Medline abstracts: PubMed | HubMed

Assigned Papers

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  1. Error fetching PMID 20205762: [Anderson2010]
  2. Error fetching PMID 25525459: [Alnahhas2014]
All Medline abstracts: PubMed | HubMed

Supplementary Information