Digital Genetic Circuits (Microbes as Machines)

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Example of a logic gate from [1].

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These gates are perhaps the farthest away from any natural counterpart and are thus likely to occupy synthetic and systems biologists in the years to come [2].

Required Reading/Viewing

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  1. Error fetching PMID 23539178: [Bonnet2013]
    Describes using recombinases to implement digital logic in bacteria.
  2. Error fetching PMID 23641100: [Benenson2013]
    Accompanying perspective article.
  3. Transcriptors & Boolean Integrase Logic (BIL) gates, explained (YouTube) [Endy2013]
    Movie in which Drew Endy explains these "transcriptors".
All Medline abstracts: PubMed | HubMed

Assigned Papers

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  1. Error fetching PMID 25395541: [Farzadfard2015]
    Scalable system for recording "cellular memories" in a genome.
  2. Error fetching PMID 25417166: [Green2014]
    Scalable construction of complex genetic circuits with wide dynamic ranges.
All Medline abstracts: PubMed | HubMed