Metabolic Engineering (Microbes as Machines)
From SynBioCyc
Download Pre-Discussion Questions (PDF)
However, it is not possible to chemically synthesize all natural products in an economical manner, despite advances in synthetic organic chemistry during the past century; for example, the potent antimalarial drug precursor artemisinin cannot be economically produced by chemical synthesis alone [1].
Required Reading/Viewing
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Summary of how economical semi-synthetic production of artemisinin was achieved in engineered yeast - Turning Sugar into High Performance Fuel: CNN's The Next List Profiles Jay Keasling (Watch on YouTube)
CNN Interview with Jay Keasling that mentions artemisinin and also focuses on biofuels.
Assigned Papers
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Addicting E. coli to caffeine by metabolic engineering - Error fetching PMID 24038353:
Optimizing the production of different chromophores by altering the violacein pathway - Error fetching PMID 22509035:
Refactoring a nitrogen fixation gene cluster