Metabolic Engineering (Microbes as Machines)

From SynBioCyc
Jump to: navigation, search
Using synthetic biology to produce artemisinin [1].

Download Pre-Discussion Questions (PDF)

However, it is not possible to chemically synthesize all natural products in an economical manner, despite advances in synthetic organic chemistry during the past century; for example, the potent antimalarial drug precursor artemisinin cannot be economically produced by chemical synthesis alone [1].

Required Reading/Viewing

Error fetching PMID 24686413:
  1. Error fetching PMID 24686413: [Paddon2014]
    Summary of how economical semi-synthetic production of artemisinin was achieved in engineered yeast
  2. Turning Sugar into High Performance Fuel: CNN's The Next List Profiles Jay Keasling (Watch on YouTube) [JBEI2013]
    CNN Interview with Jay Keasling that mentions artemisinin and also focuses on biofuels.

Assigned Papers

Error fetching PMID 23654268:
Error fetching PMID 24038353:
Error fetching PMID 22509035:
  1. Error fetching PMID 23654268: [Quandti2014]
    Addicting E. coli to caffeine by metabolic engineering
  2. Error fetching PMID 24038353: [Lee2013]
    Optimizing the production of different chromophores by altering the violacein pathway
  3. Error fetching PMID 22509035: [Temme2012]
    Refactoring a nitrogen fixation gene cluster
All Medline abstracts: PubMed | HubMed