Probiotics versus Microbiome Engineering (Biotechnology and Society 2016)

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There are more bacterial cells in your body than human ones. (Image from this site)

Required Reading/Viewing

  1. [1] "How our microbes make us who we are". (17 min)
    Talk by Rob Knight about the human microbiome, Feb 2014.
  2. [2] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering.
  3. [3] Achievements and future prospects in microbiome engineering.
  4. NIH Microbiome Project. Ethical concerns of microbiome research and probiotics. Read abstract for each section.

1. Fecal Transplants

Extra Links for the Policy Czar

  1. [4] Fecal microbiome transplant in the treatment of C. difficile
  2. [5] History of fecal transplants.
  3. [6] Slideshow summary of fecal microbiome transplants by gastroenterologists (some medical jargon, but informative).
  4. [7] Do it yourself fecal transplants. Yep.

2. Microbiome and Obesity

Extra Links for the Policy Czar

  1. [8] Summary of possible mechanisms relating gut microbiome to obesity.
  2. [9] Recent review critiquing microbiome role in obesity.

3. Probiotic E. coli Nissle 1917

Extra Links for the Policy Czar

  1. [10] Behnsen,J., Deriu, E., Sassone-Corsi, M., Raffatellu, M. (2013) Probiotics: Properties, examples, and specific applications. CSH Persp. Med. 3:a010074.
    Concentrate on the general background and section on E. coli Nissle.
  2. [11] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. Appl Microbiol Biotechnol. 100:8693-8699.

4. Oral Microbiome Engineering

Extra Links for the Policy Czar

  1. [12] Hillman, J.D. (2002) Genetically modified Streptococcus mutans for the prevention of dental caries. Antonie Van Leeuwenhoek 82:361-366.
  2. [13] Oragenics, a company devoted to engineering the oral microbiome.

Additional Links

  1. [14] Scientists swab C-section babies with mothers' microbes