Analog Genetic Circuits (Microbes as Machines)

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Contents

Download Pre-Discussion Questions (PDF)

Repressilator [1]. Image from Wikipedia article.
The only DNA in the cells is the designed synthetic DNA sequence, including “watermark” sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process [2].

Required Reading/Viewing

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  1. Error fetching PMID 10659856: [Elowitz2000]
    Describes the artificial "repressilator" circuit.
  2. Toggle Switch and Repressilator (YouTube) [Anderson2014]

Assigned Papers

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  1. Error fetching PMID 22178928: [Prindle2012]
    Synchronization and modulation of oscillations across multiple cell populations.

Additional Resources

  1. Repressilator in TinkerCell(YouTube) [Chandran2011]
    Movie shows how to create and model the repressilator in TinkerCell