Analog Genetic Circuits (Microbes as Machines)
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Download Pre-Discussion Questions (PDF)
Such 'rational network design' may lead both to the engineering of new cellular behaviours and to an improved understanding of naturally occurring networks [2].
Required Reading/Viewing
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Describes the artificial "repressilator" circuit. - Error fetching PMID 10659857:
Describes an artificial "toggle switch" circuit. - Overview of the Toggle Switch and Repressilator (YouTube)
Assigned Papers
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Bacteria that can count to three. - Error fetching PMID 22178928:
Synchronization and modulation of oscillations across multiple cell populations.
Additional Resources
- Repressilator in TinkerCell (YouTube)
Movie shows how to create and model the repressilator in TinkerCell