Difference between revisions of "Biocontainment (Microbes as Machines)"

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[[File:Moe-Behrens_Biocontainment.png|thumb|280px|right|How mutations in biocontainment mechanisms can lead to the survival of escape mutants<cite>Moe-Behrens2013</cite>.]]  
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[[File:Moe-Behrens_Biocontainment.png|thumb|280px|right|How mutations in biocontainment mechanisms can lead to the survival of escape mutants <cite>Moe-Behrens2013</cite>.]]  
  
 
==== [[Media:Spring2015_Biocontainment_Pre-Discussion.pdf|Download Pre-Discussion Questions (PDF)]] ====
 
==== [[Media:Spring2015_Biocontainment_Pre-Discussion.pdf|Download Pre-Discussion Questions (PDF)]] ====
  
 
<blockquote>
 
<blockquote>
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...if speculations correctly predict the future use of synthetic biology, the technology will scale to large industrial volumes, introduce large numbers of synthetic organisms into the environment for bioremediation, and be used in private spaces where dispersal and disposal are difficult to monitor. <cite>Moe-Behrens2013</cite>
 
</blockquote>
 
</blockquote>
  
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<biblio>
 
<biblio>
 
#Moe-Behrens2013 pmid=23355834
 
#Moe-Behrens2013 pmid=23355834
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// Reviews the development of biocontainment technologies for organisms and recombinant genes
 
</biblio>
 
</biblio>
  
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<biblio>
 
<biblio>
 
#Malyshev2014 pmid=24805238
 
#Malyshev2014 pmid=24805238
// Using a nonnatural DNA base
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// Using a nonnatural base in DNA replicated in a living organism
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#Wright2015 pmid=24847673
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// Tests of multiple biocontainment strategies for organisms
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#Gallagher2015 pmid=25567985
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// Creation of a plasmid that prevents recombinant genes from being transferred to other organisms
 
</biblio>
 
</biblio>

Revision as of 19:32, 18 April 2015

How mutations in biocontainment mechanisms can lead to the survival of escape mutants [1].

Download Pre-Discussion Questions (PDF)

...if speculations correctly predict the future use of synthetic biology, the technology will scale to large industrial volumes, introduce large numbers of synthetic organisms into the environment for bioremediation, and be used in private spaces where dispersal and disposal are difficult to monitor. [1]

Required Reading/Viewing

Error fetching PMID 23355834:
  1. Error fetching PMID 23355834: [Moe-Behrens2013]
    Reviews the development of biocontainment technologies for organisms and recombinant genes

Assigned Papers

Error fetching PMID 24805238:
Error fetching PMID 24847673:
Error fetching PMID 25567985:
  1. Error fetching PMID 24805238: [Malyshev2014]
    Using a nonnatural base in DNA replicated in a living organism
  2. Error fetching PMID 24847673: [Wright2015]
    Tests of multiple biocontainment strategies for organisms
  3. Error fetching PMID 25567985: [Gallagher2015]
    Creation of a plasmid that prevents recombinant genes from being transferred to other organisms
All Medline abstracts: PubMed | HubMed