CH391L/S14/Introduction
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Contents |
Introduction to Synthetic Biology
Overview of course structure and topics
CH391L Spring 2014 Course Syllabus
Introduce the Format of course, grading, and policies.
Synthetic biology concept map
Drew Endy on Synthetic Biology
Endy interview #2
Revisit the concept map.
Cartagena Protocol on Biosafety
Challenges in Synthetic Biology
- Evolutionary breakdown of engineered systems (i.e. The organism decides it doesn't like its engineering).
- Escape of recombinant organisms and synthetic genes from the laboratory.
- Engagement with and educating the general public (e.g. genetically modified foods).
- Dual Use resources
Timeline of Synthetic Biology
Year | Event |
---|---|
1970 | Discovery of first site-specific restriction enzyme [1] |
1972 | First publication on recombinant DNA [2] |
1976 | First genome sequenced- Bacteriophage MS2 [3] |
1981 | Introduction of phosphoramidite method of DNA oligonucleotide synthesis. [4] |
1983 | First genetically modified plant is produced [5] |
2000 | The "Repressilator" [6] |
2002 | Creation of the first synthetic virus [7] |
2003 | First use of the term "BioBrick" [8] First chemically synthesized bacteriophage genome assembled [9] |
2004 | First iGEM Jamboree |
2005 | "Adventures in Synthetic Biology" Nature Cover |
2006 | Human Genome Project completed [10] |
2007 | First application of context-free grammars in CAD software for Synthetic Biology (GenoCAD) [11] |
2008 | First synthetic genome assembled [12] |
2010 | Creation of Mycoplasma mycoides JCVI-syn1.0, the first microbe with a self-replicating synthetic genome. [13] |
2012 | Storage of digital information using DNA popularized in the media, Economist (Archives Could Last Thousands of Years when Stored on DNA) |
Wiki editing
Examples from Spring 2013:
Ancestral Sequence Reconstruction
How to edit a wiki: Instructions for Wiki Editing
First Assignment: using, editing, and critiquing a wiki page
Ethics and standards
- Do NOT delete other people's work or comments.
- Always preview your changes before saving them.
- DO NOT use copyrighted material unless you have permission.
- ALWAYS CITE material or concepts used from sources;DO NOT PLAGIARIZE