CH391L/S14/Introduction

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Contents

Introduction to Synthetic Biology

Overview of course structure and topics

CH391L Spring 2014 Course Syllabus

Introduce the Format of course, grading, and policies.

[1]

[2]

Synthetic biology concept map

E. chromi video

Transgenic Spidergoats

Drew Endy on Synthetic Biology

Endy interview #2

Timeline of Synthetic Biology

Year Event
1970 Discovery of first site-specific restriction enzyme [1]
1972 First publication on recombinant DNA [2]
1976 First genome sequenced- Bacteriophage MS2 [3]
1981 Introduction of phosphoramidite method of DNA oligonucleotide synthesis. [4]
1983 First genetically modified plant is produced [5]
2000 The "Repressilator" [6]
2002 Creation of the first synthetic virus [7]
2003 First use of the term "BioBrick" [8] First chemically synthesized bacteriophage genome assembled [9]
2004 First iGEM Jamboree
2005 "Adventures in Synthetic Biology" Nature Cover
2006 Human Genome Project completed [10]
2007 First application of context-free grammars in CAD software for Synthetic Biology (GenoCAD) [11]
2008 First synthetic genome assembled [12]
2010 Creation of Mycoplasma mycoides JCVI-syn1.0, the first microbe with a self-replicating synthetic genome. [13]
2012 Storage of digital information using DNA popularized in the media, Economist (Archives Could Last Thousands of Years when Stored on DNA)

Wiki editing

Examples from Spring 2013:

Ancestral Sequence Reconstruction

DNA Computing

Computer-Aided Design

How to edit a wiki: Instructions for Wiki Editing

Ethics and standards

  • Do NOT delete other people's work or comments.
  • Always preview your changes before saving them.
  • DO NOT use copyrighted material unless you have permission.
  • ALWAYS CITE material or concepts used from sources;DO NOT PLAGIARIZE