Digital Genetic Circuits (Microbes as Machines)

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Example of a logic gate from [1].

Contents

Download Pre-Discussion Questions (PDF)

These gates are perhaps the farthest away from any natural counterpart and are thus likely to occupy synthetic and systems biologists in the years to come.[2].

Required Reading/Viewing

  1. pmid= 23539178 [Bonnet2013]
    Describes using recombinases to implement digital logic in bacteria.
  2. pmid= 23641100 [Benenson2013]
    Accompanying perspective article.

Assigned Papers

  1. []

Additional Resources

  1. Transcriptors & Boolean Integrase Logic (BIL) gates, explained (YouTube) [Endy2013]
    Movie describing the results of the Bonnet2013 paper