Digital Genetic Circuits (Microbes as Machines)

Digital Genetic Circuits (Microbes as Machines)

Example of a logic gate from [1].

Download Pre-Discussion Questions (PDF)

These gates are perhaps the farthest away from any natural counterpart and are thus likely to occupy synthetic and systems biologists in the years to come.[2].

Required Reading/Viewing

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1. Describes using recombinases to implement digital logic in bacteria.

2. Accompanying perspective article.

Assigned Papers

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3. Scalable system for recording "cellular memories" in a genome.

Additional Resources

4. Transcriptors & Boolean Integrase Logic (BIL) gates, explained (YouTube)

   Movie describing the results of the Bonnet2013 paper