Dual-Use Research (Biotechnology and Society 2016)

Dual-Use Research (Biotechnology and Society 2016)

Required Reading/Viewing

Watch video (~7 min) Dual Use Research: A Dialogue (NIH Office of Science Policy)

Choose ONE among these four dual-use case study readings. The first three are from the (Federation of American Scientists) website (Federation of American Scientists).

1. Module 2.0 Synthesizing Poliovirus
2. Module 4.0 Unexpected Results in Virus Research
3. Module 7.0 Reconstruction of the 1918 Influenza Virus
4. Airborne H5N1 flu study
   • Enserink M (2012) Avian influenza. Public at last, H5N1 study offers insight into virus’s possible path to pandemic. Science 336:1494–1497. PMID: 22723387 Read at Science
   • Maher B (2012) Bird-flu research: The biosecurity oversight. Nature 485:431-434. PMID: 22622550 Read at Nature

Czars

• Find the primary literature describing the . If there are multiple papers, you may choose one.

Required Reading

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1. Describes the chemical synthesis of polio virus and the implications for bioterrorism.

2. Main scientific paper demonstrating how specific mutations lead H5N1 to become airborne transmissible in ferrets.

Additional Background

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3. History of Bioterrorism (Texas Department of State Health Services)

   More in-depth history and timelines than the assigned review.

4. More discussion of the context of the publication of the airborne H5N1 research.

5. American Anthrax Investigation Documents (FBI)

   Report on the anthrax case where letters containing spores were sent to government officials after 9/11/2001.