Expanding the Genetic Code (Microbes as Machines)

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Example of some of the genetic parts needed to reassign a codon to an unnatural amino acid[1].

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The genetic code was thought to be immutable...Recent developments demonstrate not only that the genetic code can evolve but also that rewiring translation to genetically encode more (possibly many more) than 20 amino acids, primarily by recoding UAG, is both feasible and desirable.[1]

Required Reading/Viewing

Error fetching PMID 24045798:
  1. Error fetching PMID 24045798: [ODonoghue2013]
    Overview of topic

Assigned Papers

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  1. Error fetching PMID 20307192: [Liu2010]
    Exhaustive review of the topic. Concentrate on methods for the directed evolution of new aminoacyl-tRNA synthetases.
  2. Error fetching PMID 20154731: [Neumann2010]
    Orthogonal translation systems that utilize a quadruplet codon
  3. Error fetching PMID 21926996: [Johnson2011]
    Fixing protein release factors for more efficient decoding of UAG
  4. Error fetching PMID 24136966: [Lajoie2013]
    Creating a completely blank codon with "amberless" E. coli
All Medline abstracts: PubMed | HubMed