Gene Therapy versus Human Genome Editing (Biotechnology and Society 2016)

Glybera (Alipogene tiparvovec) gene therapy

Everyone: Overview of gene therapy, germline modification, and genome synthesis

Gene Therapy emerges from disgrace to be the next big thing, again. Carl Zimmer Wired Science Blogs August 13, 2013.
Engineering the Perfect Baby Antonio Regalado MIT Technology Review March 5, 2015.
Use of CRISPR to
Scientists reveal proposal to build human genome from scratch Kelly Servick Science June 2, 2016.
Short article describing the Human Genome Project–Write meeting.

Gene Therapy: Molecular Bandage? Educational website at the University of Utah.
Especially, check out the "Tools of the Trade" and "Space Doctor" links.
Read Chapter 5: Ethical and Social Problems of Gene Therapy
Access from on-campus to read.

Everything You Need to Know About CRISPR, the New Tool that Edits DNA Sarah Zhang Gizmodo May 6, 2015.
Lanphier, E., Urnov, F., Haecker, S.E., Werner, M., and Smolenski, J. (2015). Don’t edit the human germ line. Nature 519: 410–411.

Bryant, L.M., Christopher, D.M., Giles, A.R., Hinderer, C., Rodriguez, J.L., Smith, J.B., Traxler, E.A., Tycko, J., Wojno, A.P., and Wilson, J.M. (2013). Lessons learned from the clinical development and market authorization of Glybera. Hum. Gene Ther. Clin. Dev. 24:55–64.
Chronicles the development of the first commercially available gene therapy treatment for Familial Lipoprotein Lipase Deficiency (LPLD).
Glybera - commercial gene therapy product.
Hacein-Bey-Abina, S., Garrigue, A., Wang, G.P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008). Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J. Clin. Invest. 118:3132–3142.
Scan for the major take-home message.