Difference between revisions of "Personalized Medicine: Precision versus Privacy (Biotechnology and Society 2016)"

Revision as of 17:45, 17 October 2016

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Schematic of personalized medicine. From bayerpharma.com.

Everyone: Personalized Medicine Case Study

Required Reading/Viewing

• The rise of the 'narciss-ome' Carina Dennis Nature March 16 2012.
• Examining His Own Body, Stanford Geneticist Stops Diabetes in Its Tracks Jon Cohen Science Now March 16, 2012.
• Chen R et al. (2012) Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes. Cell 148:1293–1307.

1. Personalized medicine

Extra Links for the Policy Czar

• Salari K, Watkins H, Ashley EA (2012) Personalized medicine: hope or hype? Eur Heart J 33:1564–1570.
  What are currently the most impactful areas of precision/personalized medicine? What are future areas of promise?
• Personalized medicine: Time for one-person trials Nicholas J. Schork Nature April 29, 2015.
• 23AndMe Company Website.
  $99/$199 Personalized genotyping service. What methods do they use? What information do you get? See especially, Warfarin sensitivity FAQ
• Out of regulatory limbo, 23andMe resumes some health tests and hopes to offer more Erika Check Hayden Nature October, 27 2015.
  What adjustments were made to 23AndMe services after it was temporarily shut down by the FDA? Why?

2. Crowd-sourcing medicine

Extra Links for the Policy Czar

• https://www.ncbi.nlm.nih.gov/pubmed/25562203
• http://www.raregenomics.org/

3. Privacy of Public Data

Extra Links for the Policy Czar

• http://blogs.nature.com/spoonful/2013/01/anonymity-not-guaranteed-identity-of-personal-genomic-dna-revealed-by-web-search.html
• https://www.genome.gov/24519851/
• http://biogenfutur.es/

1. Ormond2010 pmid=20434765

// Article discussing issues with using whole-genome data collected from patients.

1. Gymrek2013 pmid=23329047

// Article describing the identification of anonymous patients from genetic data.