Difference between revisions of "Wolbachia versus Gene Drives for Mosquito Control (Biotechnology and Society 2016)"

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(Everyone: Overview of Wolbachia and CRISPR Gene Drives)
 
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[[File:AAV_Gene_Therapy.jpg|350px|thumb|right|Glybera ([http://en.wikipedia.org/wiki/Alipogene_tiparvovec Alipogene tiparvovec]) gene therapy]]  
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[[File:malaria_risks.png|400px|thumb|right|Malaria map from the CDC]]  
 
==== [[Media:Wolbachia_Versus_Gene_Drives_Pre-Discussion_Questions_2016F.docx| Download Pre-Discussion Questions (MS Word)]] ====
 
==== [[Media:Wolbachia_Versus_Gene_Drives_Pre-Discussion_Questions_2016F.docx| Download Pre-Discussion Questions (MS Word)]] ====
 
==== [[Media:Policy_Czar_Template.docx | Download Policy Czar Template (MS Word)]] ====
 
==== [[Media:Policy_Czar_Template.docx | Download Policy Czar Template (MS Word)]] ====
  
== Everyone: Overview  ==
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== Everyone: Overview of Wolbachia and CRISPR Gene Drives ==
  
 
==== Required Reading/Viewing ====
 
==== Required Reading/Viewing ====
  
* https://www.youtube.com/watch?v=rD8SmacBUcU
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* [https://www.youtube.com/watch?v=rD8SmacBUcU How Mosquitoes Use Six Needles to Suck Your Blood] ''Deep Look'' via YouTube. Jun 7, 2016.
* [http://www.bloomberg.com/news/articles/2016-06-16/gates-says-altered-mosquitoes-are-next-weapon-in-malaria-fight Mosquito Is Next Weapon to Fight Malaria] Caroline Chen''Bloomberg News'' June 16, 2016.
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* [https://www.youtube.com/watch?v=5V9gbgICPKY Video of Bill Gates Releasing Mosquitoes Into Audience] TED Talk excerpt on YouTube. Jul 8, 2009.<br>You can watch the whole video [https://www.ted.com/talks/bill_gates_unplugged here] if you'd like (optional).
* https://www.youtube.com/watch?v=5V9gbgICPKY
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* [http://www.bloomberg.com/news/articles/2016-06-16/gates-says-altered-mosquitoes-are-next-weapon-in-malaria-fight Mosquito Is Next Weapon to Fight Malaria] Caroline Chen ''Bloomberg News'' June 16, 2016.<br>Watch the 4 minute video at the top of the page.
* http://nas-sites.org/gene-drives/
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* [https://www.sciencenews.org/article/gene-drives-spread-their-wings Gene drives spread their wings] Tina Saey ''Science News'' Dec 2, 1025.<br> Introduction to gene drives.
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* [https://www.wired.com/2016/08/california-city-fending-off-zika-releasing-40000-mosquitoes-every-week/ A California City Is Fending Off Zika by Releasing 40,000 Mosquitoes Every Week] Sarah Zhang ''Wired'' Aug. 4, 2016.<br>This article discusses the use of Wolbachia to control mosquitos. Note differences from CRISPR gene drive.
  
 
==== Additional Resources ====
 
==== Additional Resources ====
  
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691325/
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* Burt A. (2003) [https://www.ncbi.nlm.nih.gov/pubmed/12803906 Site-specific selfish genes as tools for the control and genetic engineering of natural populations]. ''Proc. Biol. Sci.'' '''270''':921–928.<br>Early paper discussing general concept and issues of gene drives.
* Regulating gene drives https://www.ncbi.nlm.nih.gov/pubmed/25035410
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* Concerning RNA-guided gene drives for the alteration of wild populations. https://www.ncbi.nlm.nih.gov/pubmed/?term=25035423
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== Wolbachia Czar ==
 
== Wolbachia Czar ==
  
 
==== Required Reading/Viewing ====
 
==== Required Reading/Viewing ====
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* [http://www.nature.com/news/us-reviews-plan-to-infect-mosquitoes-with-bacteria-to-stop-disease-1.19967 US reviews plan to infect mosquitoes with bacteria to stop disease] Emily Waltz ''Nature News'' May 24, 2016.
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* [https://www.scientificamerican.com/article/how-a-tiny-bacterium-called-wolbachia-could-defeat-dengue/ How a Tiny Bacterium Called Wolbachia Could Defeat Dengue] Scott O'Neill ''Scientific American'' June 1, 2015.
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* Frentiu F.D., et al. (2014) [https://www.ncbi.nlm.nih.gov/pubmed/24587459 Limited Dengue Virus Replication in Field-Collected ''Aedes aegypti'' Mosquitoes Infected with ''Wolbachia'']. ''PLoS Negl. Trop. Dis.'' '''8''':1–10.
  
* http://www.nature.com/news/us-reviews-plan-to-infect-mosquitoes-with-bacteria-to-stop-disease-1.19967
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==== Additional Resources ====
* https://www.wired.com/2016/08/california-city-fending-off-zika-releasing-40000-mosquitoes-every-week/
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* https://www.scientificamerican.com/article/how-a-tiny-bacterium-called-wolbachia-could-defeat-dengue/
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* Bull, J.J. [https://www.ncbi.nlm.nih.gov/pubmed/26160736 Evolutionary Decay and the Prospects for Long Term Disease Intervention using Engineered Insect Vectors]. ''Evol. Med. Public Heal.'' '''2015''':152-166.
* http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002688
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== Medea Gene Drive Czar ==
 
== Medea Gene Drive Czar ==
 
* Akbari, O. S., C.-H. Chen, J. M. Marshall, H. Huang, I. Antoshechkin, and B. A. Hay, 2014 Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression. ACS synthetic biology 3(12): 915–928.
 
* A synthetic gene drive system for local, reversible modification and suppression of insect populations. Akbari OS, Matzen KD, Marshall JM, Huang H, Ward CM, Hay BA. Curr Biol. 2013 Apr 22; 23(8):671-7.
 
* Comment: Insect biotechnology: controllable replacement of disease vectors. Wimmer EA. Curr Biol. 2013 May 20;23(10):R453-6.
 
* http://www.nature.com/nrg/journal/v17/n3/full/nrg.2015.34.html?WT.feed_name=subjects_synthetic-biology
 
  
 
==== Required Reading/Viewing ====
 
==== Required Reading/Viewing ====
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* Akbari, OS., et al. (2014) [https://www.ncbi.nlm.nih.gov/pubmed/23654248 Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression]. ''ACS Synthetic Biology'' '''3''':915–928.
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* Akbari OS, et al. (2013) [https://www.ncbi.nlm.nih.gov/pubmed/23541732 A synthetic gene drive system for local, reversible modification and suppression of insect populations]. ''Curr Biol.'' '''23''':671-677.
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* Wimmer EA. (2013) [https://www.ncbi.nlm.nih.gov/pubmed/23701690 Comment: Insect biotechnology: controllable replacement of disease vectors]. ''Curr Biol.'' '''23''':R453-R456.
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==== Additional Resources ====
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* Champer J, Buchman A, Akbari OS. (2016) [https://www.ncbi.nlm.nih.gov/pubmed/26875679 Cheating evolution: engineering gene drives to manipulate the fate of wild populations]. ''Nat. Rev. Genet.'' '''17''':146–159.
  
== CRISPR Gene Drive Czar ==
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== Gene Drive Ethics Czar ==
  
 
==== Required Reading/Viewing ====
 
==== Required Reading/Viewing ====
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* [http://nas-sites.org/gene-drives/ Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values] ''The National Academy of Sciences Report''<br>Look at the "4 Page report in Brief" and the other links.
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* Oye K.A., et al. (2014) [https://www.ncbi.nlm.nih.gov/pubmed/25035410 Biotechnology. Regulating gene drives.] ''Science'' '''345''':626–628.
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* Esvelt K.M., et al. [https://www.ncbi.nlm.nih.gov/pubmed/25035423 Concerning RNA-guided gene drives for the alteration of wild populations]. ''Elife'' '''3''':e03401.

Latest revision as of 16:24, 7 November 2016

Malaria map from the CDC

Download Pre-Discussion Questions (MS Word)

Download Policy Czar Template (MS Word)

Everyone: Overview of Wolbachia and CRISPR Gene Drives

Required Reading/Viewing

Additional Resources

Wolbachia Czar

Required Reading/Viewing

Additional Resources

Medea Gene Drive Czar

Required Reading/Viewing

Additional Resources

Gene Drive Ethics Czar

Required Reading/Viewing