Wolbachia versus Gene Drives for Mosquito Control (Biotechnology and Society 2016)

Wolbachia versus Gene Drives for Mosquito Control (Biotechnology and Society 2016)

Glybera (Alipogene tiparvovec) gene therapy

Everyone: Overview

Required Reading/Viewing

• https://www.sciencenews.org/article/gene-drives-spread-their-wings?mode=pick&context=170
• https://www.youtube.com/watch?v=rD8SmacBUcU
• Mosquito Is Next Weapon to Fight Malaria Caroline ChenBloomberg News June 16, 2016.
• https://www.youtube.com/watch?v=5V9gbgICPKY
• http://nas-sites.org/gene-drives/

Additional Resources

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691325/
• Regulating gene drives https://www.ncbi.nlm.nih.gov/pubmed/25035410
• Concerning RNA-guided gene drives for the alteration of wild populations. https://www.ncbi.nlm.nih.gov/pubmed/?term=25035423

Wolbachia Czar

Required Reading/Viewing

• http://www.nature.com/news/us-reviews-plan-to-infect-mosquitoes-with-bacteria-to-stop-disease-1.19967
• https://www.wired.com/2016/08/california-city-fending-off-zika-releasing-40000-mosquitoes-every-week/
• https://www.scientificamerican.com/article/how-a-tiny-bacterium-called-wolbachia-could-defeat-dengue/
• http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002688

Medea Gene Drive Czar

• Akbari, O. S., C.-H. Chen, J. M. Marshall, H. Huang, I. Antoshechkin, and B. A. Hay, 2014 Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression. ACS synthetic biology 3(12): 915–928.
• A synthetic gene drive system for local, reversible modification and suppression of insect populations. Akbari OS, Matzen KD, Marshall JM, Huang H, Ward CM, Hay BA. Curr Biol. 2013 Apr 22; 23(8):671-7.
• Comment: Insect biotechnology: controllable replacement of disease vectors. Wimmer EA. Curr Biol. 2013 May 20;23(10):R453-6.
• http://www.nature.com/nrg/journal/v17/n3/full/nrg.2015.34.html?WT.feed_name=subjects_synthetic-biology