Difference between revisions of "Gene Therapy versus Human Genome Editing (Biotechnology and Society 2016)"
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[[File:AAV_Gene_Therapy.jpg|350px|thumb|right|Glybera ([http://en.wikipedia.org/wiki/Alipogene_tiparvovec Alipogene tiparvovec]) gene therapy]] | [[File:AAV_Gene_Therapy.jpg|350px|thumb|right|Glybera ([http://en.wikipedia.org/wiki/Alipogene_tiparvovec Alipogene tiparvovec]) gene therapy]] | ||
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==== [[Media:Gene_Therapy_Versus_Human_Germline_Modification_Pre-Discussion_Questions_2016F.docx| Download Pre-Discussion Questions (MS Word)]] ==== | ==== [[Media:Gene_Therapy_Versus_Human_Germline_Modification_Pre-Discussion_Questions_2016F.docx| Download Pre-Discussion Questions (MS Word)]] ==== | ||
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==== [[Media:Policy_Czar_Template.docx | Download Policy Czar Template (MS Word)]] ==== | ==== [[Media:Policy_Czar_Template.docx | Download Policy Czar Template (MS Word)]] ==== | ||
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== Everyone: Overview of gene therapy, germline modification, and genome synthesis == | == Everyone: Overview of gene therapy, germline modification, and genome synthesis == | ||
| − | == Required Reading/Viewing == | + | ==== Required Reading/Viewing ==== |
* [https://www.wired.com/2013/08/the-fall-and-rise-of-gene-therapy-2/ Gene Therapy emerges from disgrace to be the next big thing, again.] Carl Zimmer ''Wired Science Blogs'' August 13, 2013. | * [https://www.wired.com/2013/08/the-fall-and-rise-of-gene-therapy-2/ Gene Therapy emerges from disgrace to be the next big thing, again.] Carl Zimmer ''Wired Science Blogs'' August 13, 2013. | ||
| − | * [https://www.technologyreview.com/s/535661/engineering-the-perfect-baby/ Engineering the Perfect Baby] Antonio Regalado ''MIT Technology Review'' March 5, 2015. <br>Use of CRISPR | + | * [https://www.technologyreview.com/s/535661/engineering-the-perfect-baby/ Engineering the Perfect Baby] Antonio Regalado ''MIT Technology Review'' March 5, 2015. <br>Use of CRISPR for human germline editing. |
* [http://www.sciencemag.org/news/2016/06/scientists-reveal-proposal-build-human-genome-scratch Scientists reveal proposal to build human genome from scratch] Kelly Servick ''Science'' June 2, 2016. <br>Short article describing the Human Genome Project–Write meeting. | * [http://www.sciencemag.org/news/2016/06/scientists-reveal-proposal-build-human-genome-scratch Scientists reveal proposal to build human genome from scratch] Kelly Servick ''Science'' June 2, 2016. <br>Short article describing the Human Genome Project–Write meeting. | ||
==== Additional Resources ==== | ==== Additional Resources ==== | ||
| − | * [http://learn.genetics.utah.edu/content | + | * [http://learn.genetics.utah.edu/content/genetherapy/ Gene Therapy: Molecular Bandage?] Educational website at the University of Utah. <br>Especially, check out the "Tools of the Trade" and "Space Doctor" links. |
* [http://link.springer.com/chapter/10.1007/978-88-470-1643-9_5 Read Chapter 5: Ethical and Social Problems of Gene Therapy]<br>Access from on-campus to read. | * [http://link.springer.com/chapter/10.1007/978-88-470-1643-9_5 Read Chapter 5: Ethical and Social Problems of Gene Therapy]<br>Access from on-campus to read. | ||
== CRISPR Germline Modification Czar == | == CRISPR Germline Modification Czar == | ||
| + | ==== Required Reading/Viewing ==== | ||
* [http://gizmodo.com/everything-you-need-to-know-about-crispr-the-new-tool-1702114381 Everything You Need to Know About CRISPR, the New Tool that Edits DNA] Sarah Zhang ''Gizmodo'' May 6, 2015. | * [http://gizmodo.com/everything-you-need-to-know-about-crispr-the-new-tool-1702114381 Everything You Need to Know About CRISPR, the New Tool that Edits DNA] Sarah Zhang ''Gizmodo'' May 6, 2015. | ||
* [http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378#/b1 Chinese scientists genetically modify human embryos] Cyranoski and Reardon. ''Nature News'' April 22, 2015. | * [http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378#/b1 Chinese scientists genetically modify human embryos] Cyranoski and Reardon. ''Nature News'' April 22, 2015. | ||
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==== Required Reading/Viewing ==== | ==== Required Reading/Viewing ==== | ||
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* Hacein-Bey-Abina, S., Garrigue, A., Wang, G.P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008). [https://www.ncbi.nlm.nih.gov/pubmed/18688285 Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.] ''J. Clin. Invest.'' '''118''':3132–3142. <br>Scan for the major take-home message. | * Hacein-Bey-Abina, S., Garrigue, A., Wang, G.P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008). [https://www.ncbi.nlm.nih.gov/pubmed/18688285 Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.] ''J. Clin. Invest.'' '''118''':3132–3142. <br>Scan for the major take-home message. | ||
* Bryant, L.M., Christopher, D.M., Giles, A.R., Hinderer, C., Rodriguez, J.L., Smith, J.B., Traxler, E.A., Tycko, J., Wojno, A.P., and Wilson, J.M. (2013). [https://www.ncbi.nlm.nih.gov/pubmed/23808604 Lessons learned from the clinical development and market authorization of Glybera.] ''Hum. Gene Ther. Clin. Dev.'' '''24''':55–64. <br>Chronicles the development of the first commercially available gene therapy treatment for Familial Lipoprotein Lipase Deficiency (LPLD). | * Bryant, L.M., Christopher, D.M., Giles, A.R., Hinderer, C., Rodriguez, J.L., Smith, J.B., Traxler, E.A., Tycko, J., Wojno, A.P., and Wilson, J.M. (2013). [https://www.ncbi.nlm.nih.gov/pubmed/23808604 Lessons learned from the clinical development and market authorization of Glybera.] ''Hum. Gene Ther. Clin. Dev.'' '''24''':55–64. <br>Chronicles the development of the first commercially available gene therapy treatment for Familial Lipoprotein Lipase Deficiency (LPLD). | ||
*[http://www.uniqure.com/products/glybera/ Glybera] - commercial gene therapy product. | *[http://www.uniqure.com/products/glybera/ Glybera] - commercial gene therapy product. | ||
Latest revision as of 03:58, 31 October 2016
Download Pre-Discussion Questions (MS Word)
Download Policy Czar Template (MS Word)
Everyone: Overview of gene therapy, germline modification, and genome synthesis
Required Reading/Viewing
- Gene Therapy emerges from disgrace to be the next big thing, again. Carl Zimmer Wired Science Blogs August 13, 2013.
- Engineering the Perfect Baby Antonio Regalado MIT Technology Review March 5, 2015.
Use of CRISPR for human germline editing. - Scientists reveal proposal to build human genome from scratch Kelly Servick Science June 2, 2016.
Short article describing the Human Genome Project–Write meeting.
Additional Resources
- Gene Therapy: Molecular Bandage? Educational website at the University of Utah.
Especially, check out the "Tools of the Trade" and "Space Doctor" links. - Read Chapter 5: Ethical and Social Problems of Gene Therapy
Access from on-campus to read.
CRISPR Germline Modification Czar
Required Reading/Viewing
- Everything You Need to Know About CRISPR, the New Tool that Edits DNA Sarah Zhang Gizmodo May 6, 2015.
- Chinese scientists genetically modify human embryos Cyranoski and Reardon. Nature News April 22, 2015.
- Editing Human Embryos: So This Happened Carl Zimmer National Geographic Blogs: The Loom April 22, 2015.
- Lanphier, E., Urnov, F., Haecker, S.E., Werner, M., and Smolenski, J. (2015). Don’t edit the human germ line. Nature 519: 410–411.
- Baltimore, B.D., Berg, P., Botchan, M., Carroll, D., Charo, R.A., Church, G., Corn, J.E., Daley, G.Q., Doudna, J.A., Fenner, M., et al. (2015). A prudent path forward for genomic engineering and germline gene modification. Science 348:36–38.
Gene Therapy Czar
Required Reading/Viewing
- Hacein-Bey-Abina, S., Garrigue, A., Wang, G.P., Soulier, J., Lim, A., Morillon, E., Clappier, E., Caccavelli, L., Delabesse, E., Beldjord, K., et al. (2008). Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J. Clin. Invest. 118:3132–3142.
Scan for the major take-home message. - Bryant, L.M., Christopher, D.M., Giles, A.R., Hinderer, C., Rodriguez, J.L., Smith, J.B., Traxler, E.A., Tycko, J., Wojno, A.P., and Wilson, J.M. (2013). Lessons learned from the clinical development and market authorization of Glybera. Hum. Gene Ther. Clin. Dev. 24:55–64.
Chronicles the development of the first commercially available gene therapy treatment for Familial Lipoprotein Lipase Deficiency (LPLD). - Glybera - commercial gene therapy product.
