Difference between revisions of "Probiotics versus Microbiome Engineering (Biotechnology and Society 2016)"
From SynBioCyc
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==== Required Reading/Viewing ==== | ==== Required Reading/Viewing ==== | ||
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# [https://www.ted.com/talks/rob_knight_how_our_microbes_make_us_who_we_are] "How our microbes make us who we are". (17 min) <br> Talk by Rob Knight about the human microbiome, Feb 2014. | # [https://www.ted.com/talks/rob_knight_how_our_microbes_make_us_who_we_are] "How our microbes make us who we are". (17 min) <br> Talk by Rob Knight about the human microbiome, Feb 2014. | ||
# [http://www.nature.com/nature/journal/v518/n7540_supp/full/518S10a.html] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering. | # [http://www.nature.com/nature/journal/v518/n7540_supp/full/518S10a.html] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering. | ||
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==== Extra Links for the Policy Czar ==== | ==== Extra Links for the Policy Czar ==== | ||
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# [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365524/] Fecal microbiome transplant in the treatment of C. difficile | # [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365524/] Fecal microbiome transplant in the treatment of C. difficile | ||
# [http://www.nature.com/ajg/journal/v107/n11/pdf/ajg2012251a.pdf] History of fecal transplants. | # [http://www.nature.com/ajg/journal/v107/n11/pdf/ajg2012251a.pdf] History of fecal transplants. | ||
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==== Extra Links for the Policy Czar==== | ==== Extra Links for the Policy Czar==== | ||
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# [http://www.nature.com/ctg/journal/v6/n6/full/ctg201516a.html] Summary of possible mechanisms relating gut microbiome to obesity.<br> | # [http://www.nature.com/ctg/journal/v6/n6/full/ctg201516a.html] Summary of possible mechanisms relating gut microbiome to obesity.<br> | ||
# [http://mbio.asm.org/content/7/4/e01018-16] Recent review critiquing microbiome role in obesity. | # [http://mbio.asm.org/content/7/4/e01018-16] Recent review critiquing microbiome role in obesity. | ||
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==== Extra Links for the Policy Czar ==== | ==== Extra Links for the Policy Czar ==== | ||
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# [https://www.ncbi.nlm.nih.gov/pubmed/27640192] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. ''Appl Microbiol Biotechnol.'' '''100''':8693-8699. | # [https://www.ncbi.nlm.nih.gov/pubmed/27640192] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. ''Appl Microbiol Biotechnol.'' '''100''':8693-8699. | ||
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==== Extra Links for the Policy Czar ==== | ==== Extra Links for the Policy Czar ==== | ||
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# [https://www.ncbi.nlm.nih.gov/pubmed/12369203] Hillman, J.D. (2002) Genetically modified ''Streptococcus mutans'' for the prevention of dental caries. ''Antonie Van Leeuwenhoek'' '''82''':361-366. | # [https://www.ncbi.nlm.nih.gov/pubmed/12369203] Hillman, J.D. (2002) Genetically modified ''Streptococcus mutans'' for the prevention of dental caries. ''Antonie Van Leeuwenhoek'' '''82''':361-366. | ||
# [http://www.oragenics.com/about] Oragenics, a company devoted to engineering the oral microbiome. | # [http://www.oragenics.com/about] Oragenics, a company devoted to engineering the oral microbiome. | ||
== Additional Links == | == Additional Links == | ||
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# [http://www.nature.com/news/scientists-swab-c-section-babies-with-mothers-microbes-1.19275] Scientists swab C-section babies with mothers' microbes | # [http://www.nature.com/news/scientists-swab-c-section-babies-with-mothers-microbes-1.19275] Scientists swab C-section babies with mothers' microbes |
Revision as of 16:57, 3 October 2016
(Needs more update) Download Pre-Discussion Questions (PDF)
Download Policy Czar Template (MS Word)
Everyone
Required Reading/Viewing
- [1] "How our microbes make us who we are". (17 min)
Talk by Rob Knight about the human microbiome, Feb 2014. - [2] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering.
- [3] Achievements and future prospects in microbiome engineering.
- NIH Microbiome Project. Ethical concerns of microbiome research and probiotics. Read abstract for each section.
1. Fecal Transplants
Extra Links for the Policy Czar
- [4] Fecal microbiome transplant in the treatment of C. difficile
- [5] History of fecal transplants.
- [6] Slideshow summary of fecal microbiome transplants by gastroenterologists (some medical jargon, but informative).
- [7] Do it yourself fecal transplants. Yep.
2. Microbiome and Obesity
Extra Links for the Policy Czar
- [8] Summary of possible mechanisms relating gut microbiome to obesity.
- [9] Recent review critiquing microbiome role in obesity.
3. Probiotic E. coli Nissle 1917
Extra Links for the Policy Czar
- [10] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. Appl Microbiol Biotechnol. 100:8693-8699.
4. Oral Microbiome Engineering
Extra Links for the Policy Czar
- [11] Hillman, J.D. (2002) Genetically modified Streptococcus mutans for the prevention of dental caries. Antonie Van Leeuwenhoek 82:361-366.
- [12] Oragenics, a company devoted to engineering the oral microbiome.
Additional Links
- [13] Scientists swab C-section babies with mothers' microbes