Probiotics versus Microbiome Engineering (Biotechnology and Society 2016)
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(Needs more update) Download Pre-Discussion Questions (PDF)
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Everyone
Required Reading/Viewing
- [1] "How our microbes make us who we are". (17 min)
Talk by Rob Knight about the human microbiome, Feb 2014. - [2] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering.
- [3] Achievements and future prospects in microbiome engineering.
- NIH Microbiome Project. Ethical concerns of microbiome research and probiotics. Read abstract for each section.
1. Fecal Transplants
Extra Links for the Policy Czar
- [4] Fecal microbiome transplant in the treatment of C. difficile
- [5] History of fecal transplants.
- [6] Slideshow summary of fecal microbiome transplants by gastroenterologists (some medical jargon, but informative).
- [7] Do it yourself fecal transplants. Yep.
2. Microbiome and Obesity
Extra Links for the Policy Czar
- [8] Summary of possible mechanisms relating gut microbiome to obesity.
- [9] Recent review critiquing microbiome role in obesity.
3. Probiotic E. coli Nissle 1917
Extra Links for the Policy Czar
- [10] Behnsen,J., Deriu, E., Sassone-Corsi, M., Raffatellu, M. (2013) Probiotics: Properties, examples, and specific applications. CSH Persp. Med. 3:a010074.
Concentrate on the general background and section on E. coli Nissle. - [11] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. Appl Microbiol Biotechnol. 100:8693-8699.
4. Oral Microbiome Engineering
Extra Links for the Policy Czar
- [12] Hillman, J.D. (2002) Genetically modified Streptococcus mutans for the prevention of dental caries. Antonie Van Leeuwenhoek 82:361-366.
- [13] Oragenics, a company devoted to engineering the oral microbiome.
Additional Links
- [14] Scientists swab C-section babies with mothers' microbes