Difference between revisions of "Probiotics versus Microbiome Engineering (Biotechnology and Society 2016)"
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| − | ==== [[Media: | + | ==== [[Media:Probiotics_Versus_Microbiome_Engineering_Pre-Discussion_Questions_2016F.docx| Download Pre-Discussion Questions (MS Word)]] ==== |
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==== [[Media:Policy_Czar_Template.docx | Download Policy Czar Template (MS Word)]] ==== | ==== [[Media:Policy_Czar_Template.docx | Download Policy Czar Template (MS Word)]] ==== | ||
== Everyone == | == Everyone == | ||
| − | [[File:Microbiome sm.jpg|450px|thumb|right|There are | + | [[File:Microbiome sm.jpg|450px|thumb|right|There are more bacterial cells in your body than human ones. (Image from [http://hmpdacc.org this site]) ]] |
==== Required Reading/Viewing ==== | ==== Required Reading/Viewing ==== | ||
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# [https://www.ted.com/talks/rob_knight_how_our_microbes_make_us_who_we_are] "How our microbes make us who we are". (17 min) <br> Talk by Rob Knight about the human microbiome, Feb 2014. | # [https://www.ted.com/talks/rob_knight_how_our_microbes_make_us_who_we_are] "How our microbes make us who we are". (17 min) <br> Talk by Rob Knight about the human microbiome, Feb 2014. | ||
# [http://www.nature.com/nature/journal/v518/n7540_supp/full/518S10a.html] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering. | # [http://www.nature.com/nature/journal/v518/n7540_supp/full/518S10a.html] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering. | ||
# [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606237/] Achievements and future prospects in microbiome engineering. | # [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606237/] Achievements and future prospects in microbiome engineering. | ||
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# [http://hmpdacc.org/health/ethical.php NIH Microbiome Project.] Ethical concerns of microbiome research and probiotics. Read abstract for each section. <br> | # [http://hmpdacc.org/health/ethical.php NIH Microbiome Project.] Ethical concerns of microbiome research and probiotics. Read abstract for each section. <br> | ||
== 1. Fecal Transplants == | == 1. Fecal Transplants == | ||
| − | ==== | + | ==== Extra Links for the Policy Czar ==== |
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# [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365524/] Fecal microbiome transplant in the treatment of C. difficile | # [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365524/] Fecal microbiome transplant in the treatment of C. difficile | ||
# [http://www.nature.com/ajg/journal/v107/n11/pdf/ajg2012251a.pdf] History of fecal transplants. | # [http://www.nature.com/ajg/journal/v107/n11/pdf/ajg2012251a.pdf] History of fecal transplants. | ||
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== 2. Microbiome and Obesity == | == 2. Microbiome and Obesity == | ||
| − | ==== | + | ==== Extra Links for the Policy Czar==== |
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# [http://www.nature.com/ctg/journal/v6/n6/full/ctg201516a.html] Summary of possible mechanisms relating gut microbiome to obesity.<br> | # [http://www.nature.com/ctg/journal/v6/n6/full/ctg201516a.html] Summary of possible mechanisms relating gut microbiome to obesity.<br> | ||
# [http://mbio.asm.org/content/7/4/e01018-16] Recent review critiquing microbiome role in obesity. | # [http://mbio.asm.org/content/7/4/e01018-16] Recent review critiquing microbiome role in obesity. | ||
| − | == 3. | + | == 3. Probiotic ''E. coli'' Nissle 1917 == |
| − | ==== | + | ==== Extra Links for the Policy Czar ==== |
| − | + | # [https://www.ncbi.nlm.nih.gov/pubmed/23457295] Behnsen,J., Deriu, E., Sassone-Corsi, M., Raffatellu, M. (2013) Probiotics: Properties, examples, and specific applications. ''CSH Persp. Med.'' '''3''':a010074.<br>Concentrate on the general background and section on ''E. coli'' Nissle. | |
| − | # [ | + | # [https://www.ncbi.nlm.nih.gov/pubmed/27640192] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. ''Appl Microbiol Biotechnol.'' '''100''':8693-8699. |
| − | # [https:// | + | |
== 4. Oral Microbiome Engineering == | == 4. Oral Microbiome Engineering == | ||
| − | ==== | + | ==== Extra Links for the Policy Czar ==== |
| − | + | # [https://www.ncbi.nlm.nih.gov/pubmed/12369203] Hillman, J.D. (2002) Genetically modified ''Streptococcus mutans'' for the prevention of dental caries. ''Antonie Van Leeuwenhoek'' '''82''':361-366. | |
# [http://www.oragenics.com/about] Oragenics, a company devoted to engineering the oral microbiome. | # [http://www.oragenics.com/about] Oragenics, a company devoted to engineering the oral microbiome. | ||
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| + | == Additional Links == | ||
| + | # [http://www.nature.com/news/scientists-swab-c-section-babies-with-mothers-microbes-1.19275] Scientists swab C-section babies with mothers' microbes | ||
Latest revision as of 19:13, 10 October 2016
Download Pre-Discussion Questions (MS Word)
Download Policy Czar Template (MS Word)
Everyone
Required Reading/Viewing
- [1] "How our microbes make us who we are". (17 min)
Talk by Rob Knight about the human microbiome, Feb 2014. - [2] "Microbiome engineering." Brief Sonnenburg article on potential applications of microbiome engineering.
- [3] Achievements and future prospects in microbiome engineering.
- NIH Microbiome Project. Ethical concerns of microbiome research and probiotics. Read abstract for each section.
1. Fecal Transplants
Extra Links for the Policy Czar
- [4] Fecal microbiome transplant in the treatment of C. difficile
- [5] History of fecal transplants.
- [6] Slideshow summary of fecal microbiome transplants by gastroenterologists (some medical jargon, but informative).
- [7] Do it yourself fecal transplants. Yep.
2. Microbiome and Obesity
Extra Links for the Policy Czar
- [8] Summary of possible mechanisms relating gut microbiome to obesity.
- [9] Recent review critiquing microbiome role in obesity.
3. Probiotic E. coli Nissle 1917
Extra Links for the Policy Czar
- [10] Behnsen,J., Deriu, E., Sassone-Corsi, M., Raffatellu, M. (2013) Probiotics: Properties, examples, and specific applications. CSH Persp. Med. 3:a010074.
Concentrate on the general background and section on E. coli Nissle. - [11] Ou B., Yang Y., Tham W.L., Chen, L., Guo, J., Zhu, G. (2016) Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application. Appl Microbiol Biotechnol. 100:8693-8699.
4. Oral Microbiome Engineering
Extra Links for the Policy Czar
- [12] Hillman, J.D. (2002) Genetically modified Streptococcus mutans for the prevention of dental caries. Antonie Van Leeuwenhoek 82:361-366.
- [13] Oragenics, a company devoted to engineering the oral microbiome.
Additional Links
- [14] Scientists swab C-section babies with mothers' microbes
